Monday, April 15, 2019
Israeli Scientists 3D-Print A Tiny, Live Heart Made With Human Tissue
Israeli Scientists 3D-Print A Tiny, Live Heart Made With Human Tissue
The future is here. In a world first, Israeli scientists have created a live heart in a revolutionary new 3D printing process that combines human tissue taken from a patient.
In November, Tel Aviv University researchers said they invented the first fully personalized tissue implantengineered from a patient’s own biomaterials and cells, paving the way for new technology that would make it possible to develop any kind of tissue implant from one small fatty tissue biopsy.
Now, these same researchers created a real heart using their innovative process at the Laboratory for Tissue Engineering and Regenerative Medicine led by Professor Tal Dvir, an associate professor at Tel Aviv University’s Department of Molecular Microbiology and Biotechnology.
“This is the first time anyone anywhere has successfully engineered and printed an entire heart complete with cells, blood vessels, ventricles and chambers,” Professor Dvir said in a press briefing on Monday at the university.
The process involved taking fatty tissue, after which the cellular and a-cellular materials were then separated. While the cells were reprogrammed to become pluripotent stem cells and efficiently differentiated to cardiac or endothelial cells, the extracellular matrix (ECM), a three-dimensional network of extracellular macromolecules, such as collagen and glycoproteins, were processed into a personalized hydrogel that served as the printing “ink,” Tel Aviv University said in a statement.
The differentiated cells were then mixed with the bio-inks and were used to 3D-print patient-specific, immune-compatible cardiac patches with blood vessels and, subsequently, an entire, tiny heart.
Cardiovascular diseases are the number one cause of death worldwide, according to the World Health Organization. In 2016 alone, an estimated 17.9 million people died from heart diseases, a majority due to heart attack and stroke.
Heart transplantation is currently the only treatment available to patients with end-stage heart failure. And with a shortage of heart donors, this scientific breakthrough development may blaze a trail in the medical world, paving the way for a potential revolution in organ and tissue transplantation.
“This heart is made from human cells and patient-specific biological materials. In our process, these materials serve as the bioinks, substances made of sugars and proteins that can be used for 3D printing of complex tissue models,” Professor Dvir said.
“People have managed to 3D-print the structure of a heart in the past, but not with cells or with blood vessels. Our results demonstrate the potential of our approach for engineering personalized tissue and organ replacement in the future,” he added.
Tel Aviv University explained that in the current method for tissue engineering for regenerative medicine, cells are isolated from the patient and cultured in biomaterials, synthetic or natural, derived from plants or animals, to assemble into a functional tissue. After transplantation, they may induce an immune response that can lead to rejection of the implanted tissue.
Patients who are recipients of engineered tissues or other implants often require treatment with immuno-suppressors, which can endanger the health of the patient.
With this development, “patients will no longer have to wait for transplants or take medications to prevent their rejection. Instead, the needed organs will be printed, fully personalized for every patient,” the university said in a statement.
The process was outlined in an article titled “3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts” published on Monday in “Advanced Science,” a peer-reviewed scientific journal.
Labels:
Health,
healthcare,
Israel,
technology
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