Up to 500 Salisbury pub-goers and diners have been told to wash possessions as a precaution after nerve agent traces were found.
Trace amounts of the substance used to poison ex-Russian spy Sergei Skripal and his daughter were found on and around a table where the pair ate at Zizzi restaurant, the BBC has learned.
The table, along with other items, has been removed and destroyed.
Scientists have advised police it could take weeks for the premises to reopen.
Traces of the nerve agent were also found at the Mill pub in Salisbury.
Sergei and Yulia Skripal, who remain in a critical but stable condition in hospital, are understood to have eaten on a table away from other diners.
Prof Dame Sally Davies, the chief medical officer for England, said the risk of harm to fellow diners was "low".
The advice to wash possessions applies to anyone in either venue after 13:30 GMT on Sunday 4 March.
Clothes should be washed, ideally in a washing machine
Clothes which cannot be washed, for example if they need dry cleaning, should be double bagged in plastic until further notice
Mobile phones, handbags and other electronic items should be wiped with baby wipes, which should be bagged in plastic and put in the bin
Other items such as jewellery and glasses should be washed with warm water and detergent
Hands should be washed after the handling of any items suspected of being contaminated.
Dame Sally said after "rigorous scientific analysis" there was some concern that prolonged exposure over weeks and months could cause health problems but it was "not a subject for panic".
She said the advice was a "belt and braces" measure, adding: "The risk to the general public remains low and I am confident none of these customers or staff will have suffered harm."
BBC correspondent Kathryn Stanczyszyn said people in Salisbury are starting to ask why the advice had not been issued before now.
Dame Sally said it had been a "painstaking process" and the "scientific tests take time" but no harm had been caused by the wait.
Image captionSergei Skripal and his daughter Yulia are still critically ill in hospital
Alastair Hay, professor emeritus of environmental toxicology at the University of Leeds, said nerve agents degrade in the environment.
"Contact with moisture will lead to breakdown of the nerve agent - this is why people having visited the restaurant or pub in question last Sunday afternoon or Monday are being advised to wash their possessions," he said.
Mr Skripal, 66, and his daughter Yulia, 33, are both critically ill in hospital after being found slumped on a bench in the city on Sunday.
Det Sgt Nick Bailey, who fell ill attending the pair, remains seriously ill in hospital but has been talking to his family.
The pub and restaurant are two of five sites in Salisbury focused on by investigators.
Mr Skripal's home and the cemetery where Mr Skripal's wife and son are buried are also being examined.
At a press conference on Sunday, Chief Constable Kier Pritchard of Wiltshire Police said he was "unable to clarify" how long those crime scenes would remain closed to the public.
Image captionDet Sgt Nick Bailey remains in hospital
A 30-year-old man has been charged with breaching a cordon at one of the sites, The Maltings shopping area, on Friday night.
He was also charged with assaulting a police officer, criminal damage to a police vehicle, common assault and a racially aggravated public order offence, and is due before magistrates in Swindon on Monday.
Members of the military are assisting police for a third day having previously helped with the removal of vehicles of interest including an ambulance.
Media captionDr Richard Guthrie, a chemical weapons expert, explains how the nerve agent might have been used
More than 250 counter terrorism police are now involved in the investigation, which has yielded 200 pieces of evidence so far and more than 240 witnesses.
Mr Skripal, a retired Russian military intelligence officer, was convicted by the Russian government of passing secrets to MI6 in 2004, but given refuge in the UK in 2010 as part of a "spy swap".
Russia has denied any involvement.
Marina Litvinenko, widow of murdered former KGB agent Alexander Litvinenko, said Mr Skripal's case needs to be properly investigated before blame can be apportioned but it would appear lessons from her husband's death have not been learned.
Media captionMarina Litvinenko: 'Lessons haven't been learned'
After a public inquiry found her husband's 2006 assassination was likely to have been ordered by Russian President Vladimir Putin's orders, Mrs Litvinenko received a letter from Theresa May which said the government would "take every step to protect the UK and its people from such a crime ever being repeated".
Mrs Litvinenko told the BBC's Andrew Marr: "Unfortunately it happened again, it means something was not done and a lesson was not learned."
Image copyrightAFP/GETTY IMAGESImage captionThe advice affects anyone at the Mill pub between 13:30 on Sunday and its closure at 23.10 on Monday
She also said Russia has a "bad reputation now" and no-one in the country had been punished for her husband's death.
Home Secretary Amber Rudd said police were "proceeding at speed" and the government was "using enormous resources" to identify those responsible for the Skripal attack.
Keep these in mind as you contemplate the direction of the American government over the past 50 years and especially since the Obama election.
The Goals of Communism
(as read into the congressional record January 10, 1963, from "The Naked Communist" by Cleon Skousen)
1. U.S. acceptance of coexistence as the only alternative to atomic war.
2. U.S. willingness to capitulate in preference to engaging in atomic war.
3. Develop the illusion that total disarmament of the United States would be a demonstration of moral strength.
4. Permit free trade between all nations regardless of Communist affiliation and regardless of whether or not items could be used for war.
5. Extension of long-term loans to Russia and Soviet satellites.
6. Provide American aid to all nations regardless of Communist domination.
7. Grant recognition of Red China. Admission of Red China to the U.N.
8. Set up East and West Germany as separate states in spite of Khrushchev's promise in 1955 to settle the German question by free elections under supervision of the U.N.
9. Prolong the conferences to ban atomic tests because the United States has agreed to suspend tests as long as negotiations are in progress.
10. Allow all Soviet satellites individual representation in the U.N.
11. Promote the U.N. as the only hope for mankind. If its charter is rewritten, demand that it be set up as a one-world government with its own independent armed forces. (Some Communist leaders believe the world can be taken over as easily by the U.N. as by Moscow. Sometimes these two centers compete with each other as they are now doing in the Congo.)
12. Resist any attempt to outlaw the Communist Party.
13. Do away with all loyalty oaths.
14. Continue giving Russia access to the U.S. Patent Office.
15. Capture one or both of the political parties in the United States.
16. Use technical decisions of the courts to weaken basic American institutions by claiming their activities violate civil rights.
17. Get control of the schools. Use them as transmission belts for socialism and current Communist propaganda. Soften the curriculum. Get control of teachers' associations. Put the party line in textbooks.
18. Gain control of all student newspapers.
19. Use student riots to foment public protests against programs or organizations which are under Communist attack.
20. Infiltrate the press. Get control of book-review assignments, editorial writing, policymaking positions.
21. Gain control of key positions in radio, TV, and motion pictures.
22. Continue discrediting American culture by degrading all forms of artistic expression. An American Communist cell was told to "eliminate all good sculpture from parks and buildings, substitute shapeless, awkward and meaningless forms."
23. Control art critics and directors of art museums. "Our plan is to promote ugliness, repulsive, meaningless art."
24. Eliminate all laws governing obscenity by calling them "censorship" and a violation of free speech and free press.
25. Break down cultural standards of morality by promoting pornography and obscenity in books, magazines, motion pictures, radio, and TV.
26. Present homosexuality, degeneracy and promiscuity as "normal, natural, healthy."
27. Infiltrate the churches and replace revealed religion with "social" religion. Discredit the Bible and emphasize the need for intellectual maturity which does not need a "religious crutch."
28. Eliminate prayer or any phase of religious expression in the schools on the ground that it violates the principle of "separation of church and state."
29. Discredit the American Constitution by calling it inadequate, old-fashioned, out of step with modern needs, a hindrance to cooperation between nations on a worldwide basis.
30. Discredit the American Founding Fathers. Present them as selfish aristocrats who had no concern for the "common man."
31. Belittle all forms of American culture and discourage the teaching of American history on the ground that it was only a minor part of the "big picture." Give more emphasis to Russian history since the Communists took over.
32. Support any socialist movement to give centralized control over any part of the culture--education, social agencies, welfare programs, mental health clinics, etc.
33. Eliminate all laws or procedures which interfere with the operation of the Communist apparatus.
34. Eliminate the House Committee on Un-American Activities.
35. Discredit and eventually dismantle the FBI.
36. Infiltrate and gain control of more unions.
37. Infiltrate and gain control of big business.
38. Transfer some of the powers of arrest from the police to social agencies. Treat all behavioral problems as psychiatric disorders which no one but psychiatrists can understand.
39. Dominate the psychiatric profession and use mental health laws as a means of gaining coercive control over those who oppose Communist goals.
40. Discredit the family as an institution. Encourage promiscuity and easy divorce.
41. Emphasize the need to raise children away from the negative influence of parents. Attribute prejudices, mental blocks and retarding of children to suppressive influence of parents.
42. Create the impression that violence and insurrection are legitimate aspects of the American tradition; that students and special-interest groups should rise up and use united force to solve economic, political or social problems.
43. Overthrow all colonial governments before native populations are ready for self-government.
44. Internationalize the Panama Canal.
45. Repeal the Connally reservation so the United States cannot prevent the World Court from seizing jurisdiction over nations and individuals alike.
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